HPV16 E6 induces chromosomal instability due to polar chromosomes caused by E6AP-dependent degradation of the mitotic kinesin CENP-E

Cosper, PF; Hrycyniak, LCF; Paracha, M; Lee, DL; Wan, J; Jones, K; Bice, SA; Nickel, K; Mallick, S; Taylor, AM; Kimple, RJ; Lambert, PF; Weaver, BA

Weaver, BA (通讯作者)，Univ Wisconsin Madison, Univ Wisconsin Carbone Canc Ctr, Madison, WI 53705 USA.;Weaver, BA (通讯作者)，Univ Wisconsin Madison, McArdle Lab Canc Res, Dept Oncol, Madison, WI 53705 USA.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023; 120 (14):

Abstract

Chromosome segregation during mitosis is highly regulated to ensure production of genetically identical progeny. Recurrent mitotic errors cause chromo......

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