Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease

Patel, S; Meilandt, WJ; Erickson, RI; Chen, JH; Deshmukh, G; Estrada, AA; Fuji, RN; Gibbons, P; Gustafson, A; Harris, SF; Imperio, J; Liu, WD; Liu, XR; Liu, YC; Lyssikatos, JP; Ma, CY; Yin, JP; Lewcock, JW; Siu, M

Siu, M (reprint author), Genentech Inc, Dept Discovery Chem, 1 DNA Way, San Francisco, CA 94080 USA.; Lewcock, JW (reprint author), Genentech Inc, Dept Neurosci, 1 DNA Way, San Francisco, CA 94080 USA.; Lewcock, JW (reprint author), Denali Therapeut, San

JOURNAL OF MEDICINAL CHEMISTRY, 2017; 60 (19): 8083

Abstract

Significant data exists to suggest that dual leucine zipper kinase (DLK, MAP3K12) is a conserved regulator of neuronal degeneration following neuronal......

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