Fatty acid mimetic PBI-4547 restores metabolic homeostasis via GPR84 in mice with non-alcoholic fatty liver disease

Simard, JC; Thibodeau, JF; Leduc, M; Tremblay, M; Laverdure, A; Sarra-Bournet, F; Gagnon, W; Ouboudinar, J; Gervais, L; Felton, A; Letourneau, S; Geerts, L; Cloutier, MP; Hince, K; Corpuz, R; Blais, A; Quintela, VM; Duceppe, JS; Abbott, SD; Blais, A; Zacharie, B; Laurin, P; Laplante, SR; Kennedy, CRJ; Hebert, RL; Leblond, FA; Grouix, B; Gagnon, L

Thibodeau, JF (corresponding author), Liminal R&D Biosci Inc, 500 Blvd Cartier Ouest,Suite 150, Laval, PQ H7V 5B7, Canada.; Thibodeau, JF (corresponding author), Univ Ottawa, Kidney Res Ctr, Dept Cellular & Mol Med, Ottawa Hosp Res Inst, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada.

SCIENTIFIC REPORTS, 2020; 10 (1):

Abstract

Non-alcoholic Fatty Liver Disease (NAFLD) is the most common form of liver disease and is associated with metabolic dysregulation. Although G protein-......

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