APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice

Area-Gomez, E; Larrea, D; Pera, M; Agrawal, RR; Guilfoyle, DN; Pirhaji, L; Shannon, K; Arain, HA; Ashok, A; Chen, QY; Dillman, AA; Figueroa, HY; Cookson, MR; Gross, SS; Fraenkel, E; Duff, KE; Nuriel, T

Nuriel, T (corresponding author), Columbia Univ, Taub Inst Res Alzheimers Dis & Aging Brain, 630 West 168th St, New York, NY 10032 USA.; Nuriel, T (corresponding author), Columbia Univ, Dept Pathol & Cell Biol, 630 West 168th St, New York, NY 10032 USA.

SCIENTIFIC REPORTS, 2020; 10 (1):

Abstract

The e4 allele of apolipoprotein E (APOE) is the dominant genetic risk factor for late-onset Alzheimer's disease (AD). However, the reason for the asso......

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