Discovery of SARS-CoV-2 main protease covalent inhibitors from a DNA-encoded library selection

Ge, R; Shen, ZY; Yin, J; Chen, WH; Zhang, Q; An, YL; Tang, DW; Satz, AL; Su, WJ; Kuai, LT

Su, WJ (通讯作者)，WuXi AppTec, 288 Fute Zhong Rd, Shanghai 200131, Peoples R China.;Kuai, LT (通讯作者)，WuXi AppTec, 55 Cambridge Pkwy,8th Floor, Cambridge, MA 02142 USA.

SLAS DISCOVERY, 2022; 27 (2): 79

Abstract

Covalent inhibitors targeting the main protease (M-pro, or 3CLpro) of SARS-CoV-2 have shown promise in preclinical investigations. Herein, we report t......

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