期刊： SLAS DISCOVERY, 2021; 26 (7)
The transfer of the small protein ubiquitin to a target protein is an intricately orchestrated process called ubiquitination that results in modulatio......
Throughout recent decades, histone deacetylase (HDAC) inhibitors have shown encouraging potential in cancer treatment, and several pan-HDAC inhibitors......
期刊： SLAS DISCOVERY, 2021; 26 (2)
Over the past 20 years, the toolbox for discovering small-molecule therapeutic starting points has expanded considerably. Pharmaceutical researchers c......
Atherosclerosis is the pathological basis of most cardiovascular diseases. Reverse cholesterol transport (RCT) is a main mechanism of cholesterol home......
DNA-encoded library (DEL) technology has been used as an ultra-high-throughput screening approach for hit identification of drug targets. This process......
D-dimer is an essential diagnostic index of thrombotic diseases. Since the existing anti-D-dimer antibodies vary in quality and specificity, a search ......
期刊： SLAS DISCOVERY, 2019; 24 (2)
Hybridoma screening is a key step for the successful generation of high-affinity analyte-specific monoclonal antibodies (MAbs). This work presents an ......
期刊： SLAS DISCOVERY, 2019; 24 (7)
The Caco-2 permeability assay is a well-accepted in vitro model to evaluate compounds' potential for oral absorption at early discovery. However, for ......
期刊： SLAS DISCOVERY, 2018; 23 (1)
Amoxapine has been demonstrated to be a potent inhibitor of Escherichia coli beta-glucuronidase. This study aims to explore the factors causing unsati......
期刊： SLAS DISCOVERY, 2018; 23 (6)
Poly(ADP-ribose) polymerase 3 (PARP3) is an important member of the PARP family and shares high structural similarities with both PARP1 and PARP2. The......
期刊： SLAS DISCOVERY, 2018; 23 (8)
Antibody-triggered endocytosis (ATE) is a biological mechanism on which many therapeutic strategies are grounded, such as delivery of antibody-drug co......
期刊： SLAS DISCOVERY, 2022; 27 (2)
Covalent inhibitors targeting the main protease (M-pro, or 3CLpro) of SARS-CoV-2 have shown promise in preclinical investigations. Herein, we report t......
期刊： SLAS DISCOVERY, 2022; 27 (2)
Background: Increasing evidence suggests the immunomodulatory potential of genes in oncology. But the identification of immune attributes of genes is ......
期刊： SLAS DISCOVERY, 2022; 27 (7)
Drug discovery for obesity treatment, particularly bodily slimming, is a topic of timely importance that requires continued investigation, as the curr......
期刊： SLAS DISCOVERY, 2022; 27 (2)
KRAS, the most frequently mutated oncogene in human cancers, was considered undruggable until the identification of small molecules that bind irrevers......
