beta-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells

Miele, E; Po, A; Begalli, F; Antonucci, L; Mastronuzzi, A; Marras, CE; Carai, A; Cucchi, D; Abballe, L; Besharat, ZM; Catanzaro, G; Infante, P; Di Marcotullio, L; Canettieri, G; De Smaele, E; Screpanti, I; Locatelli, F; Ferretti, E

Ferretti, E (reprint author), Sapienza Univ, Dept Expt Med, Viale Regina Elena 291-00161, I-00161 Rome, Italy.; Ferretti, E (reprint author), Neuromed Inst, I-86077 Pozzilli, Italy.

BMC CANCER, 2017; 17 ( ):

Abstract

Background: Aberrant Sonic Hedgehog/Gli (Hh/Gli) signaling pathway is a critical regulator of Sonic hedgehog medulloblastoma (SHH-MB). Cancer stem cel......

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