Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1

Dong, BS; Jaeger, AM; Hughes, PF; Loiselle, DR; Hauck, JS; Fu, Y; Haystead, TA; Huang, JT; Thiele, DJ

Thiele, DJ (corresponding author), Duke Univ, Dept Biochem, Sch Med, Durham, NC 27710 USA.; Thiele, DJ (corresponding author), Duke Univ, Dept Pharmacol & Canc Biol, Sch Med, Durham, NC 27710 USA.; Thiele, DJ (corresponding author), Duke Univ, Dept Mol Genet & Microbiol, Sch Med, Durham, NC 27710 USA.

SCIENCE TRANSLATIONAL MEDICINE, 2020; 12 (574):

Abstract

Heat shock factor 1 (HSF1) is a cellular stress-protective transcription factor exploited by a wide range of cancers to drive proliferation, survival,......

Download PDF


Full Text Link


打开APP