Tailoring an aldo-keto reductase KmAKR for robust thermostability and catalytic efficiency by stepwise evolution and structure-guided consensus engineering

Li, SF; Xie, JY; Qiu, S; Zhou, SY; Wang, YJ; Zheng, YG

Wang, YJ (corresponding author), Zhejiang Univ Technol, Coll Biotechnol & Bioengn, Hangzhou 310014, Zhejiang, Peoples R China.

BIOORGANIC CHEMISTRY, 2021; 109 ():

Abstract

t-Butyl 6-cyano-(3R,5R)-dihydroxyhexanoate ((3R,5R)-2) is an advanced chiral diol intermediate of the cholesterol-lowering drug atorvastatin. KmAKRM5 ......

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