Targeting TGF beta R2-mutant tumors exposes vulnerabilities to stromal TGF beta blockade in pancreatic cancer

Huang, HC; Zhang, YQ; Gallegos, V; Sorrelle, N; Zaid, MM; Toombs, J; Du, WT; Wright, S; Hagopian, M; Wang, ZN; Hosein, AN; Sathe, AA; Xing, C; Koay, EJ; Driscoll, KE; Brekken, RA

Brekken, RA (reprint author), Univ Texas Southwestern Med Ctr Dallas, Hamon Ctr Therapeut Oncol Res, Dallas, TX 75390 USA.; Brekken, RA (reprint author), Univ Texas Southwestern Med Ctr Dallas, Canc Biol Grad Program, Dallas, TX 75390 USA.; Brekken, RA (r

EMBO MOLECULAR MEDICINE, 0; ():

Abstract

TGF beta is important during pancreatic ductal adenocarcinoma (PDA) progression. Canonical TGF beta signaling suppresses epithelial pancreatic cancer ......

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