KRAS(G12C)-AMG 510 interaction dynamics revealed by all-atom molecular dynamics simulations

Pantsar, T

Pantsar, T (corresponding author), Eberhard Karls Univ Tubingen, Inst Pharmaceut Sci, Dept Pharmaceut & Med Chem, Tubingen, Germany.; Pantsar, T (corresponding author), Univ Eastern Finland, Sch Pharm, Kuopio, Finland.

SCIENTIFIC REPORTS, 2020; 10 (1):

Abstract

The first KRAS(G12C) targeting inhibitor in clinical development, AMG 510, has shown promising antitumor activity in clinical trials. On the molecular......

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