Serine-linked PARP1 auto-modification controls PARP inhibitor response

Prokhorova, E; Zobel, F; Smith, R; Zentout, S; Gibbs-Seymour, I; Schutzenhofer, K; Peters, A; Groslambert, J; Zorzini, V; Agnew, T; Brognard, J; Nielsen, ML; Ahel, D; Huet, S; Suskiewicz, MJ; Ahel, I

Suskiewicz, MJ; Ahel, I (corresponding author), Univ Oxford, Sir William Dunn Sch Pathol, Oxford, England.

NATURE COMMUNICATIONS, 2021; 12 (1):

Abstract

Poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 are recruited and activated by DNA damage, resulting in ADP-ribosylation at numerous sites, both withi......

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