Endothelial MAP2K1 mutations in arteriovenous malformation activate the RAS/MAPK pathway

Smits, PJ; Konczyk, DJ; Sudduth, CL; Goss, JA; Greene, AK

Greene, AK (corresponding author), Boston Childrens Hosp, Dept Plast & Oral Surg, 300 Longwood Ave, Boston, MA 02115 USA.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020; 529 (2): 450

Abstract

Arteriovenous malformation (AVM) is a locally destructive congenital vascular anomaly caused by somatic mutations in MAP2K1. The mutation is isolated ......

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