Single-cell RNA sequencing unveils an IL-10-producing helper subset that sustains humoral immunity during persistent infection

Xin, G; Zander, R; Schauder, DM; Chen, Y; Weinstein, JS; Drobyski, WR; Tarakanova, V; Craft, J; Cui, WG

Zander, R; Cui, WG (reprint author), BloodCtr Wisconsin, Blood Res Inst, Milwaukee, WI 53213 USA.; Cui, WG (reprint author), Med Coll Wisconsin, Dept Microbiol & Mol Genet, Milwaukee, WI 53226 USA.

NATURE COMMUNICATIONS, 2018; 9 ():

Abstract

During chronic viral infection, the inflammatory function of CD4 T-cells becomes gradually attenuated. Concurrently, Th1 cells progressively acquire t......

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