Entire CD3 epsilon, delta, and gamma humanized mouse to evaluate human CD3-mediated therapeutics

Ueda, O; Wada, NA; Kinoshita, Y; Hino, H; Kakefuda, M; Ito, T; Fujii, E; Noguchi, M; Sato, K; Morita, M; Tateishi, H; Matsumoto, K; Goto, C; Kawase, Y; Kato, A; Hattori, K; Nezu, J; Ishiguro, T; Jishage, K

Ueda, O; Jishage, K (reprint author), Chugai Pharmaceut Co Ltd, Div Res, Fuji Gotemba Res Labs, 1-135 Komakado, Gotemba, Shizuoka, Japan.

SCIENTIFIC REPORTS, 2017; 7 ( ):

Abstract

T cell-mediated immunotherapy is an attractive strategy for treatment in various disease areas. In this therapeutic approach, the CD3 complex is one o......

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