AKT Inhibition in Solid Tumors With AKT1 Mutations

Hyman, DM; Smyth, LM; Donoghue, MTA; Westin, SN; Bedard, PL; Dean, EJ; Bando, H; El-Khoueiry, AB; Perez-Fidalgo, JA; Mita, A; Schellens, JHM; Chang, MT; Reichel, JB; Bouvier, N; Selcuklu, SD; Soumerai, TE; Torrisi, J; Erinjeri, JP; Ambrose, H; Barret

Hyman, DM (reprint author), Mem Sloan Kettering Canc Ctr, 300 E 66th St,Room 1353, New York, NY 10065 USA.

JOURNAL OF CLINICAL ONCOLOGY, 2017; 35 (20): 2251

Abstract

PurposeAKT1 E17K mutations are oncogenic and occur in many cancers at a low prevalence. We performed a multihistology basket study of AZD5363, an ATP-......

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