Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors

Gulati, A; Yeung, CS; Lapointe, B; Kattar, SD; Gunaydin, H; Scott, JD; Childers, KK; Methot, JL; Simov, V; Kurukulasuriya, R; Pio, B; Morriello, GJ; Liu, P; Tang, HQ; Neelamkavil, S; Wood, HB; Rada, VL; Ardolino, MJ; Yan, XC; Palte, R; Otte, K; Faltus, R; Woodhouse, J; Hegde, LG; Ciaccio, P; Minnihan, EC; DiMauro, EF; Fell, MJ; Fuller, PH; Ellis, JM

Gulati, A; Yeung, CS (corresponding author), Merck & Co Inc, 33 Ave Louis Pasteur, Boston, MA 02115 USA.

RSC MEDICINAL CHEMISTRY, 2021; 12 (7): 1164

Abstract

The discovery of potent, kinome selective, brain penetrant LRRK2 inhibitors is the focus of extensive research seeking new, disease-modifying treatmen......

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