Intratumoral electroporation of a self-amplifying RNA expressing IL-12 induces antitumor effects in mouse models of cancer

Silva-Pilipich, N; Lasarte-Cia, A; Lozano, T; Martin-Otal, C; Lasarte, JJ; Smerdou, C

Smerdou, C (通讯作者)，Cima Univ Navarra, Div Gene Therapy & Regulat Gene Express, Av Pio XII 55, Pamplona 31008, Spain.;Lasarte, JJ (通讯作者)，Cima Univ Navarra, Program Immunol & Immunotherapy, Av Pio XII 55, Pamplona 31008, Spain.

MOLECULAR THERAPY-NUCLEIC ACIDS, 2022; 29 (): 387

Abstract

Alphavirus vectors based on self-amplifying RNA (saRNA) generate high and transient levels of transgene expression and induce innate immune responses,......

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