Celastrol reverses palmitic acid (PA)-caused TLR4-MD2 activation-dependent insulin resistance via disrupting MD2-related cellular binding to PA

Zhang, X; Wang, Y; Ge, HY; Gu, YJ; Cao, FF; Yang, CX; Uzan, G; Peng, B; Zhang, DH

Peng, B; Zhang, DH (reprint author), Secondary Mil Med Univ, Shanghai Gongli Hosp, Sino French Cooperat Cent Lab, 219 Miaopu Rd, Shanghai 200135, Peoples R China.

JOURNAL OF CELLULAR PHYSIOLOGY, 2018; 233 (10): 6814

Abstract

Elevated plasma statured fatty acids (FFAs) cause TLR4/MD2 activation-dependent inflammation and insulin tolerance, which account for the occurrence a......

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