Targeting IRS-1/mPGES-1/NOX2 to inhibit the inflammatory response caused by insulin-like growth factor-I-induced activation of NF-kappa B and NLRP3 in cancer cells

Wang, C; Li, SL; Wang, Y; An, YN; Shen, KS; Wang, XF; Luan, WJ; Ma, FX; Ni, LH; Zhou, H; Liu, MY; Yu, L

Yu, L (corresponding author), Jilin Univ, Hosp 1, Coll Vet Med,Minist Educ, Inst Zoonosis,Dept Infect Dis,Key Lab Zoonosis Re, Changchun 130062, Peoples R China.

VETERINARY AND COMPARATIVE ONCOLOGY, 2020; 18 (4): 689

Abstract

The levels of insulin-like growth factor-l (IGF-1) and reactive oxygen species (ROS) are abnormally elevated in various tumour tissues, and IGF-1 has ......

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