(2R,6R)-hydroxynorketamine exerts mGlu(2) receptor-dependent antidepressant actions

Zanos, P; Highland, JN; Stewart, BW; Georgiou, P; Jenne, CE; Lovett, J; Morris, PJ; Thomas, CJ; Moaddel, R; Zarate, CA; Gould, TD

Gould, TD (reprint author), Univ Maryland, Sch Med, Dept Psychiat, Baltimore, MD 21201 USA.; Gould, TD (reprint author), Univ Maryland, Sch Med, Dept Pharmacol, Baltimore, MD 21201 USA.; Gould, TD (reprint author), Univ Maryland, Sch Med, Dept Anat & Neur

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019; 116 (13): 6441

Abstract

Currently approved antidepressant drugs often take months to take full effect, and similar to 30% of depressed patients remain treatment resistant. In......

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