Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelial-mesenchymal transition, migration, and on the pro-inflammatory phenotype

Stazi, G; Taglieri, L; Nicolai, A; Romanelli, A; Fioravanti, R; Morrone, S; Sabatino, M; Ragno, R; Taurone, S; Nebbioso, M; Carletti, R; Artico, M; Valente, S; Scarpa, S; Mai, A

Valente, S; Mai, A (reprint author), Sapienza Univ Rome, Dept Chem & Technol Drugs, Ple A Moro 5, I-00185 Rome, Italy.; Scarpa, S (reprint author), Sapienza Univ Rome, Dept Expt Med, Ple A Moro 5, I-00185 Rome, Italy.

CLINICAL EPIGENETICS, 2019; 11 (1):

Abstract

Background Glioblastoma (GBM) is the most lethal and aggressive malignant primary brain tumor in adults. After surgical resection of the tumor, the pa......

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