Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease

Kahr, WHA; Pluthero, FG; Elkadri, A; Warner, N; Drobac, M; Chen, CH; Lo, RW; Li, L; Li, R; Li, Q; Thoeni, C; Pan, J; Leung, G; Lara-Corrales, I; Murchie, R; Cutz, E; Laxer, RM; Upton, J; Roifman, CM; Yeung, RSM; Brumell, JH; Muise, AM

Kahr, WHA; Muise, AM (reprint author), Hosp Sick Children, Res Inst, Cell Biol Program, Toronto, ON M5G 0A4, Canada.; Kahr, WHA (reprint author), Univ Toronto, Div Haematol Oncol, Dept Paediat, Toronto, ON M5G 1X8, Canada.; Kahr, WHA (reprint author), Hos

NATURE COMMUNICATIONS, 2017; 8 ( ):

Abstract

Human actin-related protein 2/3 complex (Arp2/3), required for actin filament branching, has two ARPC1 component isoforms, with ARPC1B prominently exp......

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