The p38 alpha Stress Kinase Suppresses Aneuploidy Tolerance by Inhibiting Hif-1 alpha

Simoes-Sousa, S; Littler, S; Thompson, SL; Minshall, P; Whalley, H; Bakker, B; Belkot, K; Moralli, D; Bronder, D; Tighe, A; Spierings, DCJ; Bah, N; Graham, J; Nelson, L; Green, CM; Foijer, F; Townsend, PA; Taylor, SS

Taylor, SS (reprint author), Univ Manchester, Fac Biol Med & Hlth, Div Canc Sci, Manchester Canc Res Ctr, Wilmslow Rd, Manchester M20 4QL, Lancs, England.

CELL REPORTS, 2018; 25 (3): 749

Abstract

Deviating from the normal karyotype dramatically changes gene dosage, in turn decreasing the robustness of biological networks. Consequently, aneuploi......

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