The Anti-ADAMTS-5 Nanobody(R)M6495 Protects Cartilage Degradation Ex Vivo

Siebuhr, AS; Werkmann, D; Bay-Jensen, AC; Thudium, CS; Karsdal, MA; Serruys, B; Ladel, C; Michaelis, M; Lindemann, S

Siebuhr, AS (corresponding author), Nordic Biosci Biomarkers & Res, ImmunoSci, DK-2730 Herlev, Denmark.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020; 21 (17):

Abstract

Osteoarthritis (OA) is associated with cartilage breakdown, brought about by ADAMTS-5 mediated aggrecan degradation followed by MMP-derived aggrecan a......

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