HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity

Chai, QQ; Li, SA; Collins, MK; Li, RR; Ahmad, I; Johnson, SF; Frabutt, DA; Yang, ZC; Shen, XJ; Sun, LL; Hu, J; Hultquist, JF; Peterlin, BM; Zheng, YH

Zheng, YH (corresponding author), Chinese Acad Agr Sci, CAAS Michigan State Univ Joint Lab Innate Immun, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin, Peoples R China.; Zheng, YH (corresponding author), Michigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA.

CELL REPORTS, 2021; 36 (6):

Abstract

HIV-1-negative factor (Nef) protein antagonizes serine incorporator 5 (SERINC5) by redirecting this potent restriction factor to the endosomes and lys......

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