Two closed ATP- and ADP-dependent conformations in yeast Hsp90 chaperone detected by Mn(II) EPR spectroscopic techniques

Giannoulis, A; Feintuch, A; Barak, Y; Mazal, H; Albeck, S; Unger, T; Yang, F; Su, XC; Goldfarb, D

Goldfarb, D (corresponding author), Weizmann Inst Sci, Dept Chem & Biol Phys, IL-76100 Rehovot, Israel.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020; 117 (1): 395

Abstract

Hsp90 plays a central role in cell homeostasis by assisting folding and maturation of a large variety of clients. It is a homo-dimer, which functions ......

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