Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity

Randzavola, LO; Strege, K; Juzans, M; Asano, Y; Stinchcombe, JC; Gawden-Bone, CM; Seaman, MNJ; Kuijpers, TW; Griffiths, GM

Griffiths, GM (reprint author), Cambridge Inst Med Res, Cambridge CB2 0XY, England.

JOURNAL OF CLINICAL INVESTIGATION, 2019; 129 (12): 5600

Abstract

CD8 cytotoxic T lymphocytes (CTLs) rely on rapid reorganization of the branched F-actin network to drive the polarized secretion of lytic granules, in......

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