GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts

Sterner, RM; Sakemura, R; Cox, MJ; Yang, N; Khadka, RH; Forsman, CL; Hansen, MJ; Jin, F; Ayasoufi, K; Hefazi, M; Schick, KJ; Walters, DK; Ahmed, O; Chappell, D; Sahmoud, T; Durrant, C; Nevala, WK; Patnaik, MM; Pease, LR; Hedin, KE; Kay, NE; Johnson,

Kenderian, SS (reprint author), Mayo 10-30E,200 First St South West, Rochester, MN 55905 USA.

BLOOD, 2019; 133 (7): 697

Abstract

Chimeric antigen receptor T (CAR-T) cell therapy is a new pillar in cancer therapeutics; however, its application is limited by the associated toxicit......

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