Proteasomal conformation controls unfolding ability

Cresti, JR; Manfredonia, AJ; Braganca, CE; Boscia, JA; Hurley, CM; Cundiff, MD; Kraut, DA

Kraut, DA (corresponding author), Villanova Univ, Dept Chem, Villanova, PA 19085 USA.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021; 118 (25):

Abstract

The 26S proteasome is the macromolecular machine responsible for the bulk of protein degradation in eukaryotic cells. As it degrades a ubiquitinated p......

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