An engineered protein antagonist of K-Ras/B-Raf interaction

Kauke, MJ; Traxlmayr, MW; Parker, JA; Kiefer, JD; Knihtila, R; McGee, J; Verdine, G; Mattos, C; Wittrup, KD

Wittrup, KD (reprint author), MIT, Dept Chem Engn, Cambridge, MA 02139 USA.; Wittrup, KD (reprint author), MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.; Wittrup, KD (reprint author), MIT, Dept Biol Engn, 77 Massachusett

SCIENTIFIC REPORTS, 2017; 7 ( ):

Abstract

Ras is at the hub of signal transduction pathways controlling cell proliferation and survival. Its mutants, present in about 30% of human cancers, are......

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