Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency

Collet, TH; Dubern, B; Mokrosinski, J; Connors, H; Keogh, JM; de Oliveira, EM; Henning, E; Poitou-Bernert, C; Oppert, JM; Tounian, P; Marchelli, F; Alili, R; Le Beyec, J; Pepin, D; Lacorte, JM; Gottesdiener, A; Bounds, R; Sharma, S; Folster, C; Hende

Farooqi, IS (reprint author), Univ Cambridge, Metab Res Labs, Box 289,Hills Rd, Cambridge CB2 0QQ, England.; Farooqi, IS (reprint author), Addenbrookes Hosp, Wellcome Trust MRC Inst Metab Sci, NIHR Cambridge Biomed Res Ctr, Box 289,Hills Rd, Cambridge CB2

MOLECULAR METABOLISM, 2017; 6 (10): 1321

Abstract

Objective: Pro-opiomelanocortin (POMC)-derived peptides act on neurons expressing the Melanocortin 4 receptor (MC4R) to reduce body weight. Setmelanot......

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