Hypoxia Attenuates Trastuzumab Uptake and Trastuzumab-Emtansine (T-DM1) Cytotoxicity through Redistribution of Phosphorylated Caveolin-1

Chandran, VI; Mansson, AS; Barbachowska, M; Cerezo-Magana, M; Nodin, B; Joshi, B; Koppada, N; Saad, OM; Gluz, O; Isaksson, K; Borgquist, S; Jirstrom, K; Nabi, IR; Jernstrom, H; Belting, M

Chandran, VI (corresponding author), Lund Univ, Dept Clin Sci, Div Oncol & Pathol, Lund, Sweden.; Chandran, VI (corresponding author), Fred Hutchinson Canc Res Ctr, Program Immunol, Div Clin Res, Seattle, WA 98109 USA.; Belting, M (corresponding author), Lund Univ, Barngatan 4, SE-22185 Lund, Sweden.

MOLECULAR CANCER RESEARCH, 2020; 18 (4): 644

Abstract

The antibody-drug conjugate trastuzumab-emtansine (T-DM1) offers an additional treatment option for patients with HER2-amplified tumors. However, prim......

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