Targeting proteasomal deubiquitinases USP14 and UCHL5 with b-AP15 reduces 5-fluorouracil resistance in colorectal cancer cells

Ding, W; Wang, JX; Wu, JZ; Liu, AC; Jiang, LL; Zhang, HC; Meng, Y; Liu, BY; Peng, GJ; Lou, EZ; Mao, Q; Zhou, H; Tang, DL; Chen, X; Liu, JB; Shi, XP

Chen, X; Liu, JB; Shi, XP (通讯作者)，Guangzhou Med Univ, Affiliated Hosp 6, Qingyuan Peoples Hosp, Sino French Hoffmann Inst,Guangzhou Municipal & Gu, Qingyuan 511500, Peoples R China.

ACTA PHARMACOLOGICA SINICA, 2023; 44 (12): 2537

Abstract

5-Fluorouracil (5-FU) is the first-line treatment for colorectal cancer (CRC) patients, but the development of acquired resistance to 5-FU remains a b......

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