Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts Fc epsilon RI interaction

Jabs, F; Plum, M; Laursen, NS; Jensen, RK; Molgaard, B; Miehe, M; Mandolesi, M; Rauber, MM; Pfutzner, W; Jakob, T; Mobs, C; Andersen, GR; Spillner, E

Spillner, E (reprint author), Aarhus Univ, Dept Engn, Immunol Engn, DK-8000 Aarhus, Denmark.; Laursen, NS (reprint author), Aarhus Univ, Dept Mol Biol & Genet, DK-8000 Aarhus, Denmark.

NATURE COMMUNICATIONS, 2018; 9 ():

Abstract

Anti-IgE therapeutics interfere with the ability of IgE to bind to its receptors on effector cells. Here we report the crystal structure of an anti-Ig......

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