Metformin Is a Pyridoxal-5 '-phosphate (PLP)-Competitive Inhibitor of SHMT2

Tramonti, A; Cuyas, E; Encinar, J; Pietzke, M; Paone, A; Verdura, S; Arbusa, A; Martin-Castillo, B; Giardina, G; Joven, J; Vazquez, A; Contestabile, R; Cutruzzola, F; Menendez, J

Cutruzzola, F (corresponding author), Sapienza Univ Rome, Dept Biochem Sci, I-00185 Rome, Italy.; Menendez, J (corresponding author), Catalan Inst Oncol, ProCURE Program Canc Therapeut Resistance, Metab & Canc Grp, Girona 17007, Spain.; Menendez, J (corresponding author), Miguel Hernandez Univ UMH, Inst Res Dev & Innovat Biotechnol Elche IDiBE, Alicante 03202, Spain.; Menendez, J (corresponding author), Miguel Hernandez Univ UMH, Mol & Cell Biol Inst IBMC, Alicante 03202, Spain.

CANCERS, 2021; 13 (16):

Abstract

Simple Summary The mitochondrial enzyme serine hydroxymethyltransferase (SHMT2), which converts serine into glycine and generates 1C units for cell gr......

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