Semisynthesis of CRV431

Li, FX; Zhang, QZ; Li, SJ; Lin, G; Huo, XY; Lan, Y; Yang, Z

Zhang, QZ; Yang, Z (corresponding author), Peking Univ, Sch Chem Biol & Biotechnol, State Key Lab Chem Oncogen, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China.; Zhang, QZ; Yang, Z (corresponding author), Peking Univ, Sch Chem Biol & Biotechnol, Lab Chem Genom, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China.; Yang, Z (corresponding author), Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, Beijing 100871, Peoples R China.; Yang, Z (corresponding author), Peking Univ, Beijing N

ORGANIC LETTERS, 2021; 23 (9): 3421

Abstract

The non-immune-suppressive cyclophilin inhibitor CRV431 is a clinical candidate to cure nonalcoholic steatohepatitis (NASH) and has the potential to t......

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