Tryptophanemia is controlled by a tryptophan-sensing mechanism ubiquitinating tryptophan 2,3-dioxygenase

Klaessens, S; Stroobant, V; Hoffmann, D; Gyrd-Hansen, M; Pilotte, L; Vigneron, N; De Plaen, E; Van den Eynde, BJ

Van den Eynde, BJ (corresponding author), Ludwig Inst Canc Res, B-1200 Brussels, Belgium.; Van den Eynde, BJ (corresponding author), Catholic Univ Louvain, de Duve Inst, B-1200 Brussels, Belgium.; Van den Eynde, BJ (corresponding author), Univ Oxford, Ludwig Inst Canc Res, Nuffield Dept Clin Med, Oxford OX3 7DQ, England.; Van den Eynde, BJ (corresponding author), Walloon Excellence Life Sci & Biotechnol, B-1200 Brussels, Belgium.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021; 118 (23):

Abstract

Maintaining stable tryptophan levels is required to control neuronal and immune activity. We report that tryptophan homeostasis is largely controlled ......

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