Quantifying CDK inhibitor selectivity in live cells

Wells, CI; Vasta, JD; Corona, CR; Wilkinson, J; Zimprich, CA; Ingold, MR; Pickett, JE; Drewry, DH; Pugh, KM; Schwinn, MK; Hwang, B; Zegzouti, H; Huber, KVM; Cong, M; Meisenheimer, PL; Willson, TM; Robers, MB

Willson, TM (corresponding author), Univ N Carolina, UNC Eshelman Sch Pharm, Struct Genom Consortium, Chapel Hill, NC 27599 USA.; Robers, MB (corresponding author), Promega Corp, 2800 Woods Hollow Rd, Madison, WI 53711 USA.

NATURE COMMUNICATIONS, 2020; 11 (1):

Abstract

Concerted multidisciplinary efforts have led to the development of Cyclin-Dependent Kinase inhibitors (CDKi's) as small molecule drugs and chemical pr......

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