CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers

Vijayaraghavan, S; Karakas, C; Doostan, I; Chen, X; Bui, TY; Yi, M; Raghavendra, AS; Zhao, Y; Bashour, SI; Ibrahim, NK; Karuturi, M; Wang, J; Winkler, JD; Amaravadi, RK; Hunt, KK; Tripathy, D; Keyomarsi, K

Keyomarsi, K (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Expt Radiat Oncol, 6565 MD Anderson Blvd, Houston, TX 77030 USA.; Keyomarsi, K (reprint author), Univ Texas MD Anderson Canc Ctr, Grad Sch Biomed Sci, 6767 Bertner Ave, Houston, TX 77030

NATURE COMMUNICATIONS, 2017; 8 ( ):

Abstract

Deregulation of the cell cycle machinery is a hallmark of cancer. While CDK4/6 inhibitors are FDA approved (palbociclib) for treating advanced estroge......

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