Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14

Hayun, H; Coban, M; Bhagat, AK; Ozer, E; Alfonta, L; Caulfield, TR; Radisky, ES; Papo, N

Papo, N (通讯作者),Ben Gurion Univ Negev, Avram & Stella Goldstein Goren Dept Biotechnol Eng, POB 653, IL-84105 Beer Sheva, Israel.;Papo, N (通讯作者),Ben Gurion Univ Negev, Natl Inst Biotechnol Negev, POB 653, IL-84105 Beer Sheva, Israel.;Radisky, ES (通讯作者),Mayo Clin, Dept Canc Biol, Comprehens Canc Ctr, 310 Griffin Bldg,4500 San Pablo Rd, Jacksonville, FL 32224 USA.;Caulfield, TR (通讯作者),Mayo Clin, Coll Med, Dept Neurosci, Jacksonville, FL 32224 USA.;Caulfield, TR (通讯作者),Mayo Clin, Coll Med, Dept Artificial Intelligence & Informat, Jacksonville, FL 32224 USA.;Caulfield, TR (通讯作者),Mayo Clin, Coll Med, Dept Computat Biol, Jacksonville, FL 32224 USA.;Caulfield, TR (通讯作者),Mayo Clin, Dept Biochem & Mol Biol, Coll Med, Jacksonville, FL 32224 USA.

SCIENTIFIC REPORTS, 2023; 13 (1):

Abstract

Matrix metalloproteinases (MMPs) regulate the degradation of extracellular matrix (ECM) components in biological processes. MMP activity is controlled......

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