Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling

Trauelsen, M; Hiron, TK; Lin, D; Petersen, JE; Breton, B; Husted, AS; Hjorth, SA; Inoue, A; Frimurer, TM; Bouvier, M; O'Callaghan, CA; Schwartz, TW

Schwartz, TW (corresponding author), Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Basic Metab Res, Blegdamsvej 3B,Maersk Tower, DK-2200 Copenhagen, Denmark.

CELL REPORTS, 2021; 35 (11):

Abstract

Succinate functions both as a classical TCA cycle metabolite and an extracellular metabolic stress signal sensed by the mainly Gi-coupled succinate re......

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