The dietary carcinogen PhIP activates p53-dependent DNA damage response in the colon of CYP1A-humanized mice-MedSci.cn

The dietary carcinogen PhIP activates p53-dependent DNA damage response in the colon of CYP1A-humanized mice

Yang, X; Peng, HX; Luo, ZY; Luo, AL; Cai, MS; Xu, L; Wang, H

Yang, X; Wang, H (corresponding author), Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Dept Hematol, Guangzhou 510623, Guangdong, Peoples R China.

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Abstract

Species differences in the metabolism of xenobiotics by cytochrome P450 are critical in evaluating the use of experimental animals in studying toxic c......

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