Blockade of PAR-1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice

Yokono, Y; Hanada, K; Narita, M; Tatara, Y; Kawamura, Y; Miura, N; Kitayama, K; Nakata, M; Nozaka, M; Kato, T; Kudo, N; Tsushima, M; Toyama, Y; Itoh, K; Tomita, H

Tomita, H (corresponding author), Hirosaki Univ, Grad Sch Med, Dept Cardiol & Nephrol, 5 Zaifu Cho, Hirosaki, Aomori 0368562, Japan.

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2020; 9 (12):

Abstract

BACKGROUND: Although PAR-1 (protease-activated receptor-1) exerts important functions in the pathophysiology of the cardiovascular system, the role of......

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