KRAS(G12C) Inhibition with Sotorasib in Advanced Solid Tumors

Hong, DS; Fakih, MG; Strickler, JH; Desai, J; Durm, GA; Shapiro, GI; Falchook, GS; Price, TJ; Sacher, A; Denlinger, CS; Bang, YJ; Dy, GK; Krauss, JC; Kuboki, Y; Kuo, JC; Coveler, AL; Park, K; Kim, TW; Barlesi, F; Munster, PN; Ramalingam, SS; Burns, TF; Meric-Bernstam, F; Henary, H; Ngang, J; Ngarmchamnanrith, G; Kim, J; Houk, BE; Canon, J; Lipford, JR; Friberg, G; Lito, P; Govindan, R; Li, BT

NEW ENGLAND JOURNAL OF MEDICINE, 2020; 383 (13): 1207

Abstract

BACKGROUND No therapies for targeting KRAS mutations in cancer have been approved. The KRAS p.G12C mutation occurs in 13% of non-small-cell lung cance......

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