PD-1(+) regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer

Kamada, T; Togashi, Y; Tay, C; Ha, D; Sasaki, A; Nakamura, Y; Sato, E; Fukuoka, S; Tada, Y; Tanaka, A; Morikawa, H; Kawazoe, A; Kinoshita, T; Shitara, K; Sakaguchi, S; Nishikawa, H

Nishikawa, H (reprint author), Natl Canc Ctr, Exploratory Oncol Res & Clin Trial Ctr, Res Inst, Div Canc Immunol, Tokyo 1040045, Japan.; Nishikawa, H (reprint author), Nagoya Univ, Grad Sch Med, Dept Immunol, Nagoya, Aichi 4668550, Japan.; Sakaguchi, S (r

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019; 116 (20): 9999

Abstract

PD-1 blockade is a cancer immunotherapy effective in various types of cancer. In a fraction of treated patients, however, it causes rapid cancer progr......

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