Viral vector-mediated expression of NaV1.1, after seizure onset, reduces epilepsy in mice with Dravet syndrome

Fadila, S; Beucher, B; Dopeso-Reyes, IG; Mavashov, A; Brusel, M; Anderson, K; Ismeurt, C; Goldberg, EM; Ricobaraza, A; Hernandez-Alcoceba, R; Kremer, EJ; Rubinstein, M

Kremer, EJ (通讯作者),Inst Genet Mol Montpellier, 1919 Route Mende, F-34293 Montpellier, France.;Rubinstein, M (通讯作者),Tel Aviv Univ, Fac Med, IL-6139001 Tel Aviv, Israel.

JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (12):

Abstract

Dravet syndrome (DS), an intractable childhood epileptic encephalopathy with a high fatality rate, is typically caused by loss-of-function mutations i......

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