Exploiting RAS Nucleotide Cycling as a Strategy for Drugging RAS-Driven Cancers

Mattox, TE; Chen, X; Maxuitenko, YY; Keeton, AB; Piazza, GA

Mattox, TE (corresponding author), Univ S Alabama, Mitchell Canc Inst, Drug Discovery Res Ctr, Mobile, AL 36604 USA.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020; 21 (1):

Abstract

Oncogenic mutations in RAS genes result in the elevation of cellular active RAS protein levels and increased signal propagation through downstream pat......

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