Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects

Lin, YY; Grinter, SZ; Lu, ZJ; Xu, XJ; Wang, HZ; Liang, HW; Hou, PN; Gao, JY; Clausen, C; Shi, JY; Zhao, WS; Ma, ZW; Liu, YF; White, KM; Zhao, L; Kang, PW; Zhang, GH; Cohen, IS; Zou, XQ; Cui, JM

Cui, JM (corresponding author), Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USA.; Cui, JM (corresponding author), Washington Univ, Ctr Invest Membrane Excitabil Disorders, St Louis, MO 63130 USA.; Cui, JM (corresponding author), Washington Univ, Cardiac Bioelectr & Arrhythmia Ctr, St Louis, MO 63130 USA.; Zou, XQ (corresponding author), Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA.; Zou, XQ (corresponding author), Univ Missouri, Inst Data Sci & Informat, Columbia, M

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021; 118 (20):

Abstract

Cardiac arrhythmias are the most common cause of sudden cardiac death worldwide. Lengthening the ventricular action potential duration (APD), either c......

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