TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation

Qin, Y; Li, Q; Liang, WB; Yan, RZ; Tong, L; Jia, MT; Zhao, CY; Zhao, W

Zhao, W (corresponding author), Shandong Univ, Cheeloo Coll Med, Sch Basic Med Sci, Dept Pathogen Biol, Jinan, Shandong, Peoples R China.; Zhao, W (corresponding author), Shandong Univ, Cheeloo Coll Med, Sch Basic Med Sci, Key Lab Infect & Immun Shandong Prov, Jinan, Shandong, Peoples R China.

NATURE COMMUNICATIONS, 2021; 12 (1):

Abstract

The cellular NLRP3 protein level is crucial for assembly and activation of the NLRP3 inflammasome. Various posttranslational modifications (PTMs), inc......

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